Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.
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In addition, Mannitol is non-hygroscopic and may thus be used with moisture-sensitive ingredients. Then they were subjected to different tapings of 25, 50, 75 and and the volume was noted after each step of tapings as v.
Now the volume is noted as v o. Footnotes Source of Support: A total of 3 g of granules were weighed and transferred to a measuring cylinder. Preparation of coprocessed superdisintegrant A blend of Mannitol- Mucilage was added to 65 ml of isopropyl alcohol in different concentrations. The angle of coprpcessed was then calculated using following formula.
IR study was used to check the compatibility between drug and polymer. Hence, CaCO 3 which gives alkaline medium is added as the co-processing excipient by which the disintegration and dissolution profiles were improved. Results and Discussion Terbutaline sulphate is most commonly used drug in the treatment of asthma. However, the main disadvantage is that, in preparation of new formulations, the fixed proportion of coproecssed co-processed excipients ocprocessed to be used to get synergistic effect which is not possible in every case.
FDA defines ODT as a solid dosage form which contains a medicinal substance or active ingredient which disintegrates rapidly within a matter of seconds when placed upon a tongue [ 4 ]. All the results of the post-compression tests were satisfactory and were within the pharmacopoeial limits.
The tablets were prepared by direct coprofessed method and the physical properties of tablets such as hardness, friability and dissolution profiles of tablets were evaluated. The results were represented in Table 3. As given in Table excipiemts, Terbutaline sulphate and coprocessed superdisintegrant were individually weighed and mixed thoroughly for about 5 min.
Heckel and Kawakita analysis of granules of the crude leaves extract of vernoniagalamensis prepared using poly vinyl pyrrolidone excpients binder. The purpose of the present study was to evaluate novel superdisintegrant. It is calculated as:. These coprocessed excipients interact at sub particle level. Mucilage showed fair flow properties which after coprocessing when interacted at sub particle level was improved to excellent flow property.
In vitro dissolution studies were performed for all tablet formulations by using United States Pharmacopeia dissolution apparatus type-II. Sufficient quantity of water was added in the cylinder and shaken vigoursly. SSG which disintegrated within 11 sec at the concentration of 1 gm: The direct compression method is most widely accepted process for hydrophobic drugs to be formulated into tablet dosage excipienst.
The results are depicted in Table 6. Super disintegrants are generally used for developing mouth dissolving tablets which has the requirement of faster disintegration. The different evaluation parameters of tablet like weight variation, hardness, friability, disintegration time, drug content, drug release etc.
Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation
After 30 days the samples were withdrawn and characterized for weight variation, hardness, disintegration time, drug content and in vitro drug release study. The friability of the granules was found out using Roche friabilator. The coprocessed mucilage having DT upto 7 sec and shows drug release upto The drug-excipients interaction study was carried out using method descried in Cartensen and analysis done using FTIR spectrophotometer [ 13 ].
Terbutaline sulphate is most commonly used drug in the treatment of asthma. Natural material Ocimum bascilium due to its high swelling capacity disintegrate the tablet very fast.
In this study, acacia and calcium carbonate CaCO 3 were used to prepare a co-processing excipient suitable for the preparation of atorvastatin calcium tablets. Evaluations The different evaluation parameters of tablet like weight variation, hardness, friability, disintegration time, drug content, drug release etc.
Marcel Dekker Inc; All materials used in the study complied with pharmaceutical and analytical standards.